Catheter associated thrombosis is an ongoing problem. Omniphobic coatings based on tethering biocompatible liquid lubricants on self-assembled monolayers of hydrophobic organosilanes attenuate clotting on surfaces. Herein we report an efficient, non-invasive and robust process for coating catheters with an antithrombotic, omniphobic lubricant-infused coating produced using chemical vapor deposition (CVD) of hydrophobic fluorine-based organosilanes. Compared with uncoated catheters, CVD coated catheters significantly attenuated thrombosis via the contact pathway of coagulation. When compared with the commonly used technique of liquid phase deposition (LPD) of fluorine-based organosilanes, the CVD method was more efficient and reproducible, resulted in less disruption of the outer polymeric layer of the catheters and produced greater antithrombotic activity. Therefore, omniphobic coating of catheters using the CVD method is a simple, straightforward and non-invasive procedure. This method has the potential to not only prevent catheter thrombosis, but also to prevent thrombosis on other blood-contacting medical devices.

中文翻译：

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通过疏水性有机硅烷的化学气相沉积产生的憎油润滑剂注入涂层可减轻导管表面的凝结。

导管相关的血栓形成是一个持续的问题。基于疏水性有机硅烷自组装单分子层上的生物相容性液体润滑剂的束缚疏水涂层，可减轻表面的凝结。本文中，我们报告了一种高效，无创且坚固的工艺，该工艺是在导管上涂上一层疏水性的，憎油性的，憎油性的，注入性涂层，该涂层是使用疏水性氟基有机硅烷的化学气相沉积（CVD）方法制成的。与未涂覆的导管相比，CVD涂覆的导管通过凝血的接触途径显着减轻了血栓形成。与常用的氟基有机硅烷液相沉积（LPD）技术相比，CVD方法更有效，更可重现，从而减少了导管的外部聚合物层的破坏，并产生了更大的抗血栓形成活性。因此，使用CVD方法对导管进行整体涂层是一种简单，直接且非侵入性的过程。该方法不仅可以防止导管血栓形成，而且还可以防止其他与血液接触的医疗设备发生血栓形成。