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Natural clovanes from the gorgonian coral Rumphella antipathies.
Natural Product Communications ( IF 1.5 ) Pub Date : 2013 Aug
Chung, Hsu-Ming, Wang, Wei-Hsien, Hwang, Tsong-Long, Wu, Yang-Chang, Sung, Ping-Jyun

Three natural clovane-related sesquiterpenoids, 2beta-acetoxyclovan-9alpha-ol (1), 9alpha-acetoxyclovan-2beta-ol (2) and clovan-2beta,9beta-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

中文翻译:

来自戈尔古尼亚珊瑚伦弗拉抗病性的天然丁香。

从戈尔贡珊瑚珊瑚小球藻分离物中分离出三种天然的与丁香烷相关的倍半萜类化合物:2beta-乙酰氧基丁香9alpha-ol(1),9alpha-乙酰氧基丁香2beta-ol(2)和clovan-2beta,9beta-二醇(3)。通过光谱方法并通过将光谱数据与已知的氯乙烯类似物的光谱数据进行比较,阐明了氯乙烯1-3的结构。这是首次从天然来源中分离出1-3号克隆。丁香树1和2对人类中性粒细胞对超氧阴离子的产生和弹性蛋白酶的释放具有抑制作用。
更新日期:2017-01-31
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