Electrochemical Interpretation of Propagation of the Change in the Membrane Potential Using the Goldman‐Hodgkin‐Katz Equation,Electroanalysis

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Electrochemical Interpretation of Propagation of the Change in the Membrane Potential Using the Goldman‐Hodgkin‐Katz Equation
Electroanalysis ( IF 2.7 ) Pub Date : 2017-09-12 , DOI: 10.1002/elan.201700368
O. Shirai ₁ , Y. Kitazumi ₁ , K. Kano ₁

Affiliation

Nerve conduction has been frequently explained by the Hodgkin‐Huxley equation based on the flow of K⁺ and Na⁺ across the cell membrane. By considering the relation between the membrane potential and the membrane current based on the Goldman‐Hodgkin‐Katz equation, it becomes clear that the conventional analysis using the voltage‐clamp method is not correct and that the hyperpolarization condition is artificially made. Taking into account the channel functions and the electronic properties, we suggested a new propagation mechanism. When the nerve cell is excited by an external stimulus, the ligand‐gated channels at the synapse serve as an electric power source to propagate the change in the membrane potential to the synapse terminal along the axon and the voltage‐gated channels at the axon locally assist the directional propagation along the axon.

中文翻译：

使用Goldman-Hodgkin-Katz方程的膜电位变化传播的电化学解释

神经传导经常通过基于K ⁺和Na ⁺流动的Hodgkin-Huxley方程进行解释。跨过细胞膜通过基于高盛-霍奇金-卡兹方程来考虑膜电位与膜电流之间的关系，可以清楚地看到，使用电压钳方法的常规分析是不正确的，并且是人为地制造了超极化条件。考虑到通道功能和电子特性，我们提出了一种新的传播机制。当神经细胞被外部刺激激发时，突触上的配体门控通道充当电源，将膜电位的变化沿轴突传播到突触末端，而轴突上的电压门控通道则局部传播。协助沿轴突的定向传播。

更新日期：2017-09-12

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