In the present research, a new method of sulfate radical-based advanced oxidation process was developed for the degradation of bisphenol A (BPA). In this regard, magnetite nanoparticles supported on carbon ([email protected]), as a heterostructure catalyst was combined with UV light and ultrasound (US) irradiation to efficient activate peroxymonosulfate ([email protected]/UV/US/PMS). Several parameters affecting the degradation efficiency including pH, reaction time, different concentrations of catalyst, BPA and PMS, US power and water matrix components were studied. BPA degradation rate was considerably enhanced when US and UV irradiations were applied simultaneously with [email protected] for activate PMS. A possible oxidation mechanism and reaction pathway for BPA degradation was proposed. Under optimized conditions, complete removal of BPA was obtained while the mineralization degree was only 56.4%. Toxicity tests with activated sludge demonstrate that [email protected]/UV/US/PMS system could be improved the biodegradability of the solution. The quenching experiments proved that both OH and SO₄⁻ radicals participate significantly during the degradation of BPA and sulfate radicals were dominant species. The [email protected] also show a high synergistic effect (42.6%) on the BPA degradation in the presence of the other used agents during [email protected]/UV/US/PMS system. I_OUR decreased substantially after 60 min treatment, confirming the toxicity of intermediates eliminated by process. The catalytic performance in degrade BPA was decreased at the presence of anions follows the order of HCO₃⁻ > H₂PO₄⁻ > NO₃⁻ > SO₄²⁻ > Cl⁻. Cycling tests indicate the [email protected] was reusable to activate PMS for degrade BPA for six consecutive cycles and the removal efficiency still remains at 95.2%. Overall, these results reveal that the activation of PMS by [email protected]/UV/US system is an efficient and promising advances oxidation technology for the treatment of BPA-contaminated waters and wastewaters.