A rapid and efficient single-step synthesis of substituted anilines has been developed. The aromatic nitro compounds were reduced by using reducing systems generated by the action of an excess of LiAlH₄ on TiCl₄. Anilines substituted with different functional groups were synthesized in high yields and purity starting from the corresponding nitro compounds. The developed procedure is applicable to nitroaromatics containing both electron withdrawing and electron donating substituents. Substrates with electron donor substituents require a larger excess of LiAlH₄. The reducing power of the prepared reactant systems depends on the used molar ratio of LiAlH₄ and TiCl₄.

中文翻译：

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LiAlH4 / TiCl4还原芳香族硝基化合物的简单合成苯胺

已经开发了快速有效的取代苯胺单步合成法。通过使用还原系统还原芳族硝基化合物，该还原系统是由过量的LiAlH ₄对TiCl ₄的作用所产生的。从相应的硝基化合物开始，以高收率和高纯度合成了被不同官能团取代的苯胺。所开发的方法适用于同时具有吸电子和给电子取代基的硝基芳族化合物。具有电子给体取代基的基材需要大量过量的LiAlH ₄。制备的反应物体系的还原能力取决于所使用的LiAlH ₄和TiCl _4的摩尔比。