Catalytic Asymmetric Oxidative α-C–H N,O-Ketalization of Ketones by Chiral Primary Amine,Organic Letters

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Catalytic Asymmetric Oxidative α-C–H N,O-Ketalization of Ketones by Chiral Primary Amine
Organic Letters ( IF 4.9 ) Pub Date : 2015-08-21 00:00:00 , DOI: 10.1021/acs.orglett.5b02322
Changming Xu ₁ , Long Zhang _{1,

2} , Sanzhong Luo _{1,

2}

Affiliation

A highly enantioselective primary amine catalyzed α,α-bis-functionalization of β-ketocarbonyls and cyclohexanones is described. This transformation employs N-hydroxycarbamates as both nitrogen and oxygen sources under aerobic oxidative conditions to furnish chiral N,O-ketals with high yields and enantioselectivities.

中文翻译：