Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In this study, a series of selenocysteine (Sec) and selenoglutathione (GSeH) derivatives were synthesized via 2-(trimethylsilyl)ethylselenation as a key step. Our findings suggested the relevance and application of a 2-(trimethylsilyl)ethylselenyl group to the Se-containing amino acid synthesis.

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双-2-（三甲基甲硅烷基）乙基二硒化物在合成含硒氨基酸衍生物中的应用

含硒氨基酸作为生物材料，对硒依赖性酶和修复蛋白的合成起着举足轻重的作用。特别地，硒代半胱氨酸和硒代谷胱甘肽主要参与基本的生物学过程。在这项研究中，一系列的硒代半胱氨酸（Sec）和硒代谷胱甘肽（GSeH）衍生物是通过2-（三甲基甲硅烷基）乙基硒化合成的关键步骤。我们的发现表明2-（三甲基甲硅烷基）乙基硒基与含硒氨基酸合成的相关性和应用。