A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate the body's repair mechanisms through the recruitment of endogenous stem cells to sites of injury. Approaches that employ the use of chemoattractant gradients to guide tissue regeneration without external cell sources are favored over traditional cell-based therapies that have limited potential for clinical translation. Following this concept, bioactive scaffolds can be engineered to provide a temporally and spatially controlled release of biological cues, with the possibility to mimic the complex signaling patterns of endogenous tissue regeneration. Another effective way to regulate stem cell activity is to leverage the inherent chemotactic properties of extracellular matrix (ECM)-based materials to build versatile cell-instructive platforms. This review introduces the concept of endogenous stem cell recruitment, and provides a comprehensive overview of the strategies available to achieve effective cardiovascular and bone tissue regeneration.

组织工程的一个领先策略是设计仿生支架，通过将内源干细胞募集到损伤部位来刺激身体的修复机制。与临床转化潜力有限的传统细胞疗法相比，采用化学引诱剂梯度来引导组织再生而无需外部细胞源的方法更受青睐。遵循这一概念，可以对生物活性支架进行工程设计，以提供生物信号在时间和空间上的受控释放，并有可能模拟内源性组织再生的复杂信号传导模式。调节干细胞活性的另一种有效方法是利用细胞外基质（ECM）材料固有的趋化特性来构建多功能的细胞指导平台。本综述介绍了内源干细胞募集的概念，并全面概述了可用于实现有效心血管和骨组织再生的策略。