蜕膜化和胎盘缺陷是与年龄相关的生殖衰退的主要原因。,Nature Communications

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蜕膜化和胎盘缺陷是与年龄相关的生殖衰退的主要原因。
Nature Communications ( IF 14.7 ) Pub Date : 2017-09-05 , DOI: 10.1038/s41467-017-00308-x
Laura Woods _{1,

2} , Vicente Perez-Garcia _{1,

2} , Jens Kieckbusch ₃ , Xiaoqiu Wang ₄ , Francesco DeMayo ₄ , Francesco Colucci ₃ , Myriam Hemberger _{1,

2}

Affiliation

随着母亲高龄，哺乳动物的繁殖能力迅速下降。这种效应很大程度上归因于卵母细胞中染色体分离错误随着年龄的增长呈指数增加。然而，许多妊娠并发症和出生缺陷在高龄母亲中更为常见，无论是在人类还是小鼠中，都是在没有核型异常的情况下发生的。在这里，我们报告说，老年雌性小鼠的胚胎发育异常与严重的胎盘缺陷有关，这是由子宫基质的蜕膜化反应的严重缺陷引起的。这个问题的根源在于衰老子宫的荷尔蒙反应减弱。重要的是，年轻的子宫环境可以恢复正常的胎盘和胚胎发育。我们的数据强调了孕产妇年龄对子宫妊娠适应性的关键影响（尽管未被充分认识），是导致老年女性生殖成功率下降的主要原因。孕产妇高龄与生殖成功率较低和妊娠并发症风险较高有关。在这里，作者表明，小鼠中与母亲衰老相关的胚胎异常是由蜕膜化和胎盘缺陷引起的，可以通过将胚胎从年老子宫移植到年轻子宫来挽救这些缺陷。

"点击查看英文标题和摘要"

Decidualisation and placentation defects are a major cause of age-related reproductive decline.

Mammalian reproductive performance declines rapidly with advanced maternal age. This effect is largely attributed to the exponential increase in chromosome segregation errors in the oocyte with age. Yet many pregnancy complications and birth defects that become more frequent in older mothers, in both humans and mice, occur in the absence of karyotypic abnormalities. Here, we report that abnormal embryonic development in aged female mice is associated with severe placentation defects, which result from major deficits in the decidualisation response of the uterine stroma. This problem is rooted in a blunted hormonal responsiveness of the ageing uterus. Importantly, a young uterine environment can restore normal placental as well as embryonic development. Our data highlight the pivotal, albeit under-appreciated, impact of maternal age on uterine adaptability to pregnancy as major contributor to the decline in reproductive success in older females.Advanced maternal age has been associated with lower reproductive success and higher risk of pregnancy complications. Here the authors show that maternal ageing-related embryonic abnormalities in mouse are caused by decidualisation and placentation defects that can be rescued by transferring the embryo from an old to a young uterus.

更新日期：2017-09-05

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