Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression,ACS Macro Letters

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Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-09-01 00:00:00 , DOI: 10.1021/acsmacrolett.7b00592
Yasuhiro Nakagawa _{1,

2} , Atsuhiro Saitou ₃ , Takao Aoyagi ₄ , Masanobu Naito _{2,

5} , Mitsuhiro Ebara _{1,

2,

6}

Affiliation

Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.

中文翻译：

用于免疫抑制的凋亡细胞膜聚合物

凋亡细胞死亡通过消除危险、受损或不必要的细胞而在不引起炎症反应的情况下通过将磷脂酰丝氨酸外化到磷脂双层的外叶而在体内平衡中发挥重要作用。在这项研究中，我们新设计了具有磷酸丝氨酸基团作为抗炎功能部分的凋亡细胞膜启发单体和聚合物，并首次证明施用凋亡细胞膜启发的磷酸丝氨酸聚合物可以保护小鼠巨噬细胞(RAW 264.7) 来自脂多糖诱导的炎症。有趣的是，具有磷酸胆碱单体的统计共聚物可以更精确地模拟凋亡细胞膜，从而更有效地抑制巨噬细胞活化。

更新日期：2017-09-01

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