The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.

中文翻译：

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Piperidin-4-one：潜在的药效团。

哌啶-4-酮已被报道为通用中间体。它们已经使用多种方法合成，包括曼尼希反应和立体选择性合成。哌啶-4-酮据报道具有多种药理活性，包括抗癌和抗HIV活性。可以适当地修饰药效团，以实现更好的受体相互作用和生物学活性。对细胞核的新兴趣重新确立了哌啶-4-酮在药物化学中的重要性。该综述旨在讨论最近十年在哌啶4-4-酮的合成方案，表征，立体化学和重要的生物学活性方面的当前研究趋势。