The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.

中文翻译：

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表皮脂质代谢在全身生理学中的意义

皮肤是人体最大的感觉器官。皮肤不仅可以防止水分和身体其他成分的流失，而且还参与调节体温并作为必不可少的屏障，保护哺乳动物免受日常和极端环境的影响。鉴于皮肤在温度调节中的重要性，令人惊讶的是，皮肤功能和形态的适应性改变与全身生理反应仅模糊地相​​关。尽管皮肤中受损的脂质代谢通常会损害皮肤的表皮渗透屏障和绝缘特性，但其在调节全身生理和代谢方面的作用仍有待认识到。