立方HfO2纳米结构的低温合成及其细胞毒性的一种新方法。,Scientific Reports

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立方HfO2纳米结构的低温合成及其细胞毒性的一种新方法。
Scientific Reports ( IF 3.8 ) Pub Date : 2017-Aug-24 , DOI: 10.1038/s41598-017-07753-0
Neeraj Kumar , Blassan Plackal Adimuriyil George , Heidi Abrahamse , Vyom Parashar , Suprakas Sinha Ray , Jane Catherine Ngila

为了在热力学稳定的单斜晶相中无法实现的独特性能的出现，必须开发一种在较低温度下稳定HfO ₂立方相的策略。生成HfO ₂的立方相需要非常高的温度（> 2600°C），而单斜晶相在低温下是稳定的。在这里，设计了一种新的快速合成策略来开发高度结晶的纯立方相HfO ₂使用微波辐射的纳米颗粒（尺寸<10 nm）。此外，通过在表面改性剂的存在下进行水后热处理，将制得的纳米颗粒转化为不同的形态（球形纳米颗粒和纳米板），而不会损害立方相。研究了合成的立方HfO ₂纳米结构在MCF-7乳腺癌细胞系中的细胞毒性和增殖情况，以及caspase-3 / 7活性。Na ₂ S·xH ₂的理想存在，是导致晶相晶格产生表面缺陷（缺陷和变形）的主要原因。O和NaOH。我们的工作为周围环境中纳米级立方相HfO ₂的稳定化提供了空前的见识；该方法可以扩展到纳米材料的其他挑战性阶段。

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A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity.

The development of a strategy to stabilise the cubic phase of HfO₂ at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO₂, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO₂ nanoparticles (size <10 nm) using microwave irradiation. Furthermore, the as-prepared nanoparticles were converted to different morphologies (spherical nanoparticles and nanoplates) without compromising the cubic phase by employing a post-hydrothermal treatment in the presence of surface modifiers. The cytotoxicities and proliferative profiles of the synthesised cubic HfO₂ nanostructures were investigated over the MCF-7 breast cancer cell line, along with caspase-3/7 activities. The low-temperature phase stabilisation was significantly attributed to surface imperfections (defects and deformations) induced in the crystal lattice by the desirable presence of Na₂S·xH₂O and NaOH. Our work provides unprecedented insight into the stabilisation of nanoscale cubic-phase HfO₂ in ambient environments; the method could be extended to other challenging phases of nanomaterials.

更新日期：2017-08-24

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