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Enantiospecific total synthesis of (−)-crotanecine
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-08-24 , DOI: 10.1016/j.tetlet.2017.08.056 Yugandhar Kothapalli , Ravi Kumar Puthukanoori , Mahesh Ranga , Srinivasa Rao Alapati
中文翻译:
对映体全合成(-)-crotanecine
更新日期:2017-08-24
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-08-24 , DOI: 10.1016/j.tetlet.2017.08.056 Yugandhar Kothapalli , Ravi Kumar Puthukanoori , Mahesh Ranga , Srinivasa Rao Alapati
Crotanecine is the necine base component of a number of pyrrolizidine alkaloids. This necine subunit is an amino triol bearing a primary allylic alcohol characterized by an all-cis relationship of its stereocenters. The synthesis of crotanecine has been accomplished using simple yet versatile ring construction approach using ribose as chiral starting point.
中文翻译:
对映体全合成(-)-crotanecine
Crotanecine是许多吡咯烷核生物碱的烟碱基础成分。该烟酸亚基是带有伯烯丙基醇的氨基三醇,其特征在于其立体中心的全顺式关系。使用核糖作为手性起点的简单而通用的环构建方法已经完成了克罗他辛的合成。