Tris(3-hydroxypropyl)phosphine (THPP) is demonstrated to be a versatile, water-soluble and air-stable reducing agent, allowing for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous–organic media. The reagent shows exceptional stability at biological pH under which condition it permits the rapid reduction of a wide range of differentially functionalized small-molecule disulfides.

中文翻译：

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三（3-羟丙基）膦（THPP）：一种温和的，空气稳定的试剂，用于快速还原还原小分子二硫化物

三（3-羟丙基）膦（THPP）被证明是一种多功能，水溶性和空气稳定的还原剂，可在水性和缓冲水性有机介质中快速，不可逆地还原二硫键。该试剂在生物pH值下显示出优异的稳定性，在此条件下，该试剂可快速还原各种不同功能的小分子二硫化物。