Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target—an oxysterol binding protein—resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont™ Zorvec™ disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented.

中文翻译：

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发现氧杂泛醇，一种靶向氧固醇结合蛋白的新型卵菌杀菌剂

Oxathiapiprolin是一类新的哌啶基噻唑异恶唑啉类杀菌剂的第一个成员，对由卵菌病原体引起的植物病害具有出色的活性。它通过抑制新型真菌靶标（氧固醇结合蛋白）发挥作用，从而对葡萄，土豆和蔬菜等关键疾病具有出色的预防，治疗和残留功效。Oxathiapiprolin作为DuPont™Zorvec™疾病控制产品正在全球范围内开发，预计于2015年首次注册和销售。其中介绍了其发现，合成，优化和生物学功效。