Reaction of Dimethyl Trisulfide with Hemoglobin,Chemical Research in Toxicology

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Reaction of Dimethyl Trisulfide with Hemoglobin
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2017-08-18 00:00:00 , DOI: 10.1021/acs.chemrestox.7b00181
Xinmei Dong ₁ , Lóránd Kiss ₁ , Ilona Petrikovics ₁ , David E. Thompson ₁

Affiliation

Dimethyl trisulfide (DMTS) is a promising antidotal candidate for cyanide intoxication. DMTS acts as a sulfur donor in the conversion of cyanide to the less-toxic thiocyanate. The alternate reaction pathways of DMTS in the blood are not well understood. We report changes in the hemoglobin absorption spectrum upon reaction with DMTS. These changes closely match those induced by the known methemoglobin former, sodium nitrite. The kinetics of methemoglobin formation with DMTS is slower than with sodium nitrite. These results support the hypothesis that a potentially significant side-reaction of the therapeutically administered DMTS is the oxidization of hemoglobin to methemoglobin.

中文翻译：

三硫化二甲基与血红蛋白的反应

二甲基三硫化物（DMTS）是氰化物中毒的有希望的解毒剂候选药物。DMTS在氰化物向毒性较低的硫氰酸盐的转化中充当硫供体。血液中DMTS的替代反应途径尚未充分了解。我们报告与DMTS反应后血红蛋白吸收光谱的变化。这些变化与已知的高铁血红蛋白形成剂亚硝酸钠诱导的变化非常匹配。DMTS形成高铁血红蛋白的动力学比亚硝酸钠慢。这些结果支持这样的假设：治疗性给药的DMTS的潜在显着的副反应是血红蛋白氧化为高铁血红蛋白。

更新日期：2017-08-19

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