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Rational Design of GO-Modified Fe3O4/SiO2 Nanoparticles with Combined Rhenium-188 and Gambogic Acid for Magnetic Target Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-08-18 00:00:00 , DOI: 10.1021/acsami.7b07589 Yuxiang Yang 1, 2 , Yicheng Liu 1 , Chao Cheng 3 , Haowei Shi 1 , Huan Yang 1 , Hongming Yuan 4 , Chaoying Ni 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-08-18 00:00:00 , DOI: 10.1021/acsami.7b07589 Yuxiang Yang 1, 2 , Yicheng Liu 1 , Chao Cheng 3 , Haowei Shi 1 , Huan Yang 1 , Hongming Yuan 4 , Chaoying Ni 2
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Peanutlike magnetic-fluorescent Fe3O4/SiO2 nanoparticles, with an effective dynamic diameter of 180 nm, were synthesized via EuO+ doping and coupling of two Fe3O4 cores and reassembling through the solvothermal process. Spherical pure Fe3O4/SiO2 nanoparticles with an effective dynamic diameter of 230 nm were also prepared for comparison. We designed graphene oxide (GO)-modified core–shell Fe3O4/SiO2 nanoparticles as a nanocarrier for loading gambogic acid (GA) following labeling with radioisotope rhenium-188. We also performed GA loading and releasing on GA-loaded magnetic nanoparticles, in vivo biodistribution, and magnetic drug targeting therapy experiments. Results indicated that the GA-loaded magnetic nanoparticles demonstrate a clear pH-dependent drug release behavior, having a higher release rate in acidic environments. The in vivo biodistribution of the magnetic nanoparticles has morphologic dependency, and the peanutlike nanoparticles (PN-Fe3O4) tend to accumulate more in the spleen, lung, and liver than in the spherical nanoparticles (S-Fe3O4). The targeted therapy showed a higher efficacy of PN-Fe3O4 in inhibiting tumor cell growth than the nontargeted therapy. The polyethyleneimine (PEI) grafting of PN-Fe3O4 with amide bond was also designed to find an effective active targeting antitumor agent considering the fact that the PEI–GO conjugate has a higher GA load efficiency and the convergence effect.
中文翻译：
--188和藤黄酸联合GO修饰的Fe 3 O 4 / SiO 2纳米粒子的合理设计
通过EuO +掺杂和两个Fe 3 O 4核的偶联并通过溶剂热过程重新组装，合成了花生状的磁性荧光Fe 3 O 4 / SiO 2纳米粒子，其有效动态直径为180 nm 。还制备了有效动态直径为230 nm的球形纯Fe 3 O 4 / SiO 2纳米颗粒进行比较。我们设计了氧化石墨烯（GO）改性的核壳Fe 3 O 4 / SiO 2放射性同位素rh 188标记后，可将纳米颗粒用作负载甘草酸（GA）的纳米载体。我们还对载有GA的磁性纳米颗粒进行了GA加载和释放，体内生物分布以及磁性药物靶向治疗实验。结果表明，载有GA的磁性纳米颗粒表现出明显的pH依赖性药物释放行为，在酸性环境中具有较高的释放速率。磁性纳米颗粒的体内生物分布具有形态学依赖性，花生样纳米颗粒（PN-Fe 3 O 4）较之球形纳米颗粒（S-Fe 3 O 4）倾向于在脾，肺和肝中积累更多。靶向治疗显示PN-Fe 3的疗效更高O 4比非靶向疗法在抑制肿瘤细胞生长方面更胜一筹。考虑到PEI-GO共轭物具有更高的GA负载效率和收敛效果，还设计了具有酰胺键的PN-Fe 3 O 4接枝PN-Fe 3 O 4的聚乙烯亚胺（PEI）。
更新日期：2017-08-18
中文翻译：
--188和藤黄酸联合GO修饰的Fe 3 O 4 / SiO 2纳米粒子的合理设计
通过EuO +掺杂和两个Fe 3 O 4核的偶联并通过溶剂热过程重新组装，合成了花生状的磁性荧光Fe 3 O 4 / SiO 2纳米粒子，其有效动态直径为180 nm 。还制备了有效动态直径为230 nm的球形纯Fe 3 O 4 / SiO 2纳米颗粒进行比较。我们设计了氧化石墨烯（GO）改性的核壳Fe 3 O 4 / SiO 2放射性同位素rh 188标记后，可将纳米颗粒用作负载甘草酸（GA）的纳米载体。我们还对载有GA的磁性纳米颗粒进行了GA加载和释放，体内生物分布以及磁性药物靶向治疗实验。结果表明，载有GA的磁性纳米颗粒表现出明显的pH依赖性药物释放行为，在酸性环境中具有较高的释放速率。磁性纳米颗粒的体内生物分布具有形态学依赖性，花生样纳米颗粒（PN-Fe 3 O 4）较之球形纳米颗粒（S-Fe 3 O 4）倾向于在脾，肺和肝中积累更多。靶向治疗显示PN-Fe 3的疗效更高O 4比非靶向疗法在抑制肿瘤细胞生长方面更胜一筹。考虑到PEI-GO共轭物具有更高的GA负载效率和收敛效果，还设计了具有酰胺键的PN-Fe 3 O 4接枝PN-Fe 3 O 4的聚乙烯亚胺（PEI）。
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