A dihydropyridone-mediated approach to the morphine skeleton was investigated. The hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydropyridone functionalization methods. This new approach should be useful in the design of more efficient syntheses of morphine and its derivatives.

中文翻译：

---

对吗啡骨架的新颖方法。通过N-酰基吡啶鎓盐合成1-（5-苄氧基-2-溴-4-甲氧基苄基）-6-氧代-3,4,6,7,8,8a-六氢-1H-异喹啉-2-羧酸苯基酯盐化学

研究了二氢吡啶酮介导的吗啡骨架方法。使用N-酰基吡啶鎓化学和二氢吡啶酮官能化方法以九个步骤合成六氢异喹啉2。这种新方法应在设计更高效的吗啡及其衍生物合成中有用。