The newly synthesized 1-[4-(3H-pyrrolo[3,2-f]quinolin-9-ylamino)-phenyl]-ethanone hydrochloride showed high antiproliferative activity by mixed mechanisms of action. The compound acts by forming an intercalative complex with DNA and inhibiting DNA topoisomerase II (topo II) and by blocking the cell cycle in G(2)/M phase. Probable cell death by apoptosis is also suggested by flow cytometry analysis.

中文翻译：

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发现一种新的苯胺基-3H-吡咯并[3,2-f]喹啉衍生物作为潜在的抗癌药。

新合成的1- [4-（3H-吡咯并[3,2-f]喹啉-9-氨基氨基]-苯基]-乙酮盐酸盐通过混合作用机理表现出高抗增殖活性。该化合物的作用是与DNA形成嵌入复合物并抑制DNA拓扑异构酶II（拓扑II），并阻断G（2）/ M期的细胞周期。流式细胞仪分析也提示了细胞凋亡可能导致的细胞死亡。