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New electrophilic difluoromethylating reagent.
Organic Letters ( IF 4.9 ) Pub Date : 2007 May 10 , DOI: 10.1021/ol070195g
G. K. Surya Prakash 1 , Csaba Weber 1 , Sujith Chacko 1 , George A. Olah 1
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A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.

中文翻译:

新型亲电二氟甲基化试剂。

已经开发出一种新的亲电子二氟甲基化试剂。已经显示出S-(二氟甲基)二芳基四氟硼酸be可有效地将亲电子二氟甲基引入以下亲核试剂中:磺酸,叔胺,咪唑衍生物和膦。该试剂未能将二氟甲基转移​​至苯酚,碳亲核试剂以及伯胺和仲胺。
更新日期:2017-01-31
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