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Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions.
Organic Letters ( IF 4.9 ) Pub Date : 2007 Mar 29 , DOI: 10.1021/ol070164l
Irini Akritopoulou-Zanze 1 , Alan Whitehead 1 , Jan E. Waters 1 , Rodger F. Henry 1 , Stevan W. Djuric 1
Affiliation  

[structure: see text]. We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining the Ugi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to five stereocenters; however, in most cases, only two diastereomers are observed.

中文翻译:

通过顺序的Ugi / [2 + 2]烯-烯酮光环加成反应合成新颖且形状独特的3-氮杂双环[4.2.0] octan-4-one衍生物。

[结构:见文字]。我们报告了通过结合[2 + 2]烯酮-烯烃光化学转化的Ugi多组分反应,构造新颖且形状独特的3-氮杂双环[4.2.0] octan-4-one衍生物的新方法。整个序列最多可以创建五个立体中心。但是,在大多数情况下,仅观察到两个非对映异构体。
更新日期:2017-01-31
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