DNA Trojan Horses: Self‐Assembled Floxuridine‐Containing DNA Polyhedra for Cancer Therapy,Angewandte Chemie International Edition

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DNA Trojan Horses: Self‐Assembled Floxuridine‐Containing DNA Polyhedra for Cancer Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-09-05 , DOI: 10.1002/anie.201706301
Quanbing Mou ₁ , Yuan Ma ₁ , Gaifang Pan ₁ , Bai Xue ₁ , Deyue Yan ₁ , Chuan Zhang ₁ , Xinyuan Zhu ₁

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Based on their structural similarity to natural nucleobases, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid‐phase synthesis. By elaborately designing their sequences, floxuridine‐integrated DNA strands were synthesized and self‐assembled into well‐defined DNA polyhedra with definite drug‐loading ratios as well as tunable size and morphology. As a novel drug delivery system, these drug‐containing DNA polyhedra could ideally mimic the Trojan Horse to deliver chemotherapeutics into tumor cells and fight against cancer. Both in vitro and in vivo results demonstrate that the DNA Trojan horse with buckyball architecture exhibits superior anticancer capability over the free drug and other formulations. With precise control over the drug‐loading ratio and structure of the nanocarriers, the DNA Trojan horse may play an important role in anticancer treatment and exhibit great potential in translational nanomedicine.

中文翻译：

DNA特洛伊木马：自组装的含氟尿苷的DNA多面体用于癌症治疗

基于它们与天然核碱基的结构相似性，核苷类似物疗法可通过常规固相合成方法整合到DNA链中。通过精心设计其序列，可以合成氟尿苷整合的DNA链，并将其自组装成定义明确的DNA多面体，并具有确定的载药率以及可调的大小和形态。作为一种新型的药物输送系统，这些包含药物的DNA多面体可以理想地模仿特洛伊木马，将化学治疗剂输送至肿瘤细胞并抗击癌症。体外和体内结果均表明，具有巴基球结构的DNA Trojan马表现出比游离药物和其他制剂优异的抗癌能力。通过精确控制纳米载体的载药率和结构，

更新日期：2017-09-05

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