A series of arylidenehydrazides (3a-3i) were synthesized from [6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl]acetic acid hydrazide. The structures of new compounds were determined by analytical and spectral (IR, (1)H NMR, (13)C NMR, EIMS) methods. The synthesized compounds (3a-3i) were evaluated in the National Cancer Institute's 3-cell line, one dose in vitro primary cytotoxicity assay. Compounds 3a-3c, 3h and 3i which passed the criteria for activity in this assay were scheduled automatically for evaluation against the full panel of 60 human tumour cell lines at a minimum of five concentrations at 10-fold dilutions. Compounds 3c demonstrated the most marked effects on a prostate cancer cell line (PC-3, log(10)GI(50) value<-8.00).

中文翻译：

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新型咪唑并[2,1-b]噻唑衍生物的合成及初步细胞毒性评估。

由[6-（4-溴苯基）咪唑并[2,1-b]噻唑-3-基]乙酸酰肼合成了一系列芳基酰肼（3a-3i）。通过分析和光谱（IR，（1）H NMR，（13）C NMR，EIMS）方法确定新化合物的结构。合成的化合物（3a-3i）在美国国家癌症研究所的3细胞株中进行了一次剂量的体外原代细胞毒性试验。将通过该测定法中的活性标准的化合物3a-3c，3h和3i自动排定，以针对全组的60种人类肿瘤细胞系进行评估，其浓度至少为5倍，稀释度为10倍。化合物3c对前列腺癌细胞系表现出最显着的作用（PC-3，log（10）GI（50）值<-8.00）。