Asymmetric Synthesis of Chiral Cyclopentanes Bearing an All-Carbon Quaternary Stereocenter by Zirconium-Catalyzed Double Carboalumination,Angewandte Chemie International Edition

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Asymmetric Synthesis of Chiral Cyclopentanes Bearing an All-Carbon Quaternary Stereocenter by Zirconium-Catalyzed Double Carboalumination
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-08-11 05:31:19 , DOI: 10.1002/anie.201706198
Shiqing Xu ₁ , Chuan Wang _{1,

2} , Masato Komiyama ₁ , Yasuhiko Tomonari ₁ , Ei-ichi Negishi ₁

Affiliation

All-carbon quaternary stereocenters: A zirconium-catalyzed double carboalumination of various unactivated 1,5-dienes provides efficient access to chiral cyclopentanes with two stereocenters, including one all-carbon quaternary stereocenter, through the formation of two new C−C bonds as well as one C−Al bond with high diastereo- and enantioselectivity.

中文翻译：