Three new N-methyl-4-hydroxy-2-pyridinone analogues, 6-epi-oxysporidinone (3), the dimethyl ketal of oxysporidinone (4), and N-demethylsambutoxin (5), along with the known compounds (-)-oxysporidinone (1), (-)-sambutoxin (2), wortmannin (6), enniatin A (7), enniatin A1 (8), and enniatin B1 (9) were isolated from Fusarium oxysporum (N17B) by bioassay-guided fractionation. Compounds 1 and 3 showed selective fungistatic activity against Aspergillus fumigatus, and wortmannin had selective potent activity against Candida albicans. Moderate activity was observed with the enniatins 7-9 against C. albicans, Cryptococcus neoformans, and Mycobacterium intracellulare. Compounds 1-5 had no activity against the agriculturally important fungi Fusarium verticillioides (syn. F. moniliforme) and Aspergillus flavus.

中文翻译：

---

尖孢镰刀菌（Fusarium oxysporum）的N-甲基-4-羟基-2-吡啶酮类似物。

三种新的N-甲基-4-羟基-2-吡啶酮类似物，6-表-环氧孢酮（3），羟孢酮的二甲基缩酮（4）和N-去甲基氨基丁酮（5），以及已知的化合物（-）-通过生物测定引导分级分离法从尖孢镰刀菌（Narbonus oxysporum，N17B）中分离了羟孢霉酮（1），（-）-三丁氧嗪（2），渥曼青霉素（6），烯尿素A（7），烯尿素A1（8）和烯尿素B1（9）。 。化合物1和3对烟曲霉具有选择性的抑菌活性，而渥曼青霉素对白色念珠菌具有选择性的有效活性。烯醇溶蛋白7-9对白色念珠菌，新型隐球菌和胞内分枝杆菌具有中等活性。化合物1-5对农业上重要的真菌类镰刀镰刀菌（S. F. moniliforme）和黄曲霉没有活性。