Novel oxazolidinone antibacterials containing N-hydroxyacetamidine moiety are synthesized with the diversity at C-5 terminus. These compounds have been evaluated against a panel of clinically relevant gram-positive and gram-negative pathogens. Most of the analogs in this series displayed activity superior to Linezolid and in vivo efficacies of selected oxazolidinones are also disclosed herein.

中文翻译：

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带有N-羟基乙am取代基的新型恶唑烷酮的合成及其抗菌活性。

合成了具有N-羟基乙moiety部分的新型恶唑烷酮抗菌剂，其在C-5末端具有多样性。已针对一组临床相关的革兰氏阳性和革兰氏阴性病原体对这些化合物进行了评估。该系列中的大多数类似物显示出优于利奈唑胺的活性，并且本文还公开了选定的恶唑烷酮的体内功效。