Unexpected Chiro-Thermoresponsive Behavior of Helical Poly(phenylacetylene)s Bearing Elastin-Based Side-Chains,Angewandte Chemie International Edition

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Unexpected Chiro-Thermoresponsive Behavior of Helical Poly(phenylacetylene)s Bearing Elastin-Based Side-Chains
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-08-09 07:06:41 , DOI: 10.1002/anie.201704821
Sandra Arias ₁ , Felix Freire ₁ , Marcelo Calderón ₂ , Julian Bergueiro ₂

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The thermoresponsive behavior of an elastin-based polymer can be altered by the polymeric macromolecular conformation. Thus, when the elastin basic amino acid sequence VPGVG is used as a pendant group of a poly(phenylacetylene) (PPA) its thermoresponsive behavior in water can be remotely detected through conformational changes on the formed helix. Circular dichroism at different temperatures shows an inversion of the first Cotton effect (450 nm) at 25.8 °C that matches with the cloud point temperature. The elastin-based side-chain poly(phenylacetylene) shows an upper critical solution temperature with low pH and concentration dependency, not expected in elastin-based polymers. It was found that the polymer self-assembles in water into spherical nanoparticles with hydrodynamic diameters of 140 nm at the hydrophobic state.

中文翻译：

带有弹性蛋白基侧链的螺旋聚（苯基乙炔）的意外手性热响应行为。

弹性蛋白基聚合物的热响应行为可以通过聚合物大分子构象改变。因此，当弹性蛋白碱性氨基酸序列VPGVG用作聚苯乙炔（PPA）的侧基时，可以通过形成的螺旋上的构象变化来远程检测其在水中的热响应性。在不同温度下的圆二色性显示在25.8°C时第一个Cotton效应（450 nm）的反转与浊点温度匹配。基于弹性蛋白的侧链聚苯乙炔显示出较高的临界溶液温度，具有较低的pH和浓度依赖性，这在基于弹性蛋白的聚合物中是无法预期的。发现该聚合物在水中自组装成球形纳米颗粒，在疏水状态下其流体力学直径为140 nm。

更新日期：2017-08-09

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