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An efficient access to (1H-tetrazol-5-yl)furoxan ammonium salts via a two-step dehydration/[3+2]-cycloaddition strategy
Tetrahedron ( IF 2.1 ) Pub Date : 2015-08-10 11:25:12
Leonid L. Fershtat, Margarita A. Epishina, Alexander S. Kulikov, Igor V. Ovchinnikov, Ivan V. Ananyev, Nina N. Makhova

A general, highly effective two-step approach for direct synthesis of (1H-tetrazol-5-yl)furoxan ammonium salts with various functional substituents based on initial effective synthesis of cyanofuroxans by dehydration of furoxancarboxylic acid amides by the action of (CF3CO)2O/Py followed by [3+2]-cycloaddition of cyanofuroxans to ammonium azide, generated in situ from TMSN3 and NH4F, has been developed.

中文翻译:

通过两步脱水/ [3 + 2]-环加成策略有效获得(1H-四唑-5-基)呋喃喃铵盐

一种一般高效的两步法,可直接合成具有各种功能性取代基的(1H-四唑-5-基)呋喃喃铵盐,其基础是通过(CF 3 CO)的作用使呋喃呋喃羧酸酰胺脱水而初始有效合成氰呋喃类化合物。)已开发出2 O / Py,然后由TMSN 3和NH 4 F原位生成氰呋喃类化合物到叠氮化铵的[3 + 2]-环加成反应。
更新日期:2015-08-11
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