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2,4,6-Trichloro-1,3,5-triazine and N,N′-dimethylformamide as an effective Vilsmeier–Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2015-08-10 07:04:43
P. Venkanna, K.C. Rajanna, M. Satish Kumar, Mohd. Bismillah Ansari, M. Moazzam Ali

TCTA–DMF (2,4,6-trichloro-1,3,5-triazine/N,N′-dimethylformamide) adduct has been used as a Vilsmeier–Haack type reagent for effective synthesis of 2-chloro-3-formyl quinolines from acetanilides under conventional and ultrasonically assisted conditions. The reaction times under sonication are quite significantly shorter than conventional methods even though the yields obtained under sonication are comparable with those obtained under reflux conditions.

中文翻译:

2,4,6-三氯-1,3,5-三嗪和N,N'-二甲基甲酰胺是一种有效的Vilsmeier-Haack试剂,可从乙酰苯胺合成2-氯-3-甲酰基喹啉

TCTA-DMF(2,4,6-三氯-1,3,5-三嗪/ N,N'-二甲基甲酰胺)加合物已被用作Vilsmeier-Haack型试剂,可有效合成2-氯-3-甲酰基喹啉在常规和超声辅助条件下从乙酰苯胺中提取。尽管在超声处理下获得的产率与在回流条件下获得的产率相当,但在超声处理下的反应时间明显比常规方法短得多。
更新日期:2015-08-10
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