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Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2005 Dec 1 , DOI: 10.1016/j.bmcl.2005.06.108 Helen L. Birch , George M. Buckley , Natasha Davies , Hazel J. Dyke , Elizabeth J. Frost , Philip J. Gilbert , Duncan R. Hannah , Alan F. Haughan , Michael J. Madigan , Trevor Morgan , William R. Pitt , Andrew J. Ratcliffe , Nicholas C. Ray , Marianna D. Richard , Andrew Sharpe , Alicia J. Taylor , Justine M. Whitworth , Sophie C. Williams
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2005 Dec 1 , DOI: 10.1016/j.bmcl.2005.06.108 Helen L. Birch , George M. Buckley , Natasha Davies , Hazel J. Dyke , Elizabeth J. Frost , Philip J. Gilbert , Duncan R. Hannah , Alan F. Haughan , Michael J. Madigan , Trevor Morgan , William R. Pitt , Andrew J. Ratcliffe , Nicholas C. Ray , Marianna D. Richard , Andrew Sharpe , Alicia J. Taylor , Justine M. Whitworth , Sophie C. Williams
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).
中文翻译：
作为IMPDH抑制剂的新型7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮。
描述了一系列新的7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮的合成和生物活性。发现这些化合物中的一些是II型肌苷5'-单磷酸脱氢酶（IMPDH II）的有效抑制剂。
更新日期：2017-01-31
中文翻译：
作为IMPDH抑制剂的新型7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮。
描述了一系列新的7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮的合成和生物活性。发现这些化合物中的一些是II型肌苷5'-单磷酸脱氢酶（IMPDH II）的有效抑制剂。
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