GluA1 AMPAR亚基缺失减少了对蔗糖的享乐反应，但完整的饱腹感和条件反应却保持不变。,Scientific Reports

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GluA1 AMPAR亚基缺失减少了对蔗糖的享乐反应，但完整的饱腹感和条件反应却保持不变。
Scientific Reports ( IF 3.8 ) Pub Date : 2017-Aug-07 , DOI: 10.1038/s41598-017-07542-9
Joseph M. Austen , Rolf Sprengel , David J. Sanderson

AMPA受体的GluA1亚基与精神分裂症有关。虽然GluA1对认知很重要，但尚不清楚GluA1在享乐反应中与精神分裂症等疾病的负面症状有关的作用是什么。在这里，我们使用舔micro微结构分析测试了食用蔗糖溶液时缺少GluA1的小鼠（Gria1 ^-/-小鼠）。在一定范围的蔗糖浓度下，GluA1缺失会大大降低适口性（通过平均舔团大小测量）。尽管降低了初始舔食率，但长期使用蔗糖溶液的食用量度不受GluA1缺失和Gria1 ^-/-的影响小鼠对高蔗糖浓度表现出正常的饱腹感反应。GluA1缺失也未能损害风味调理，其中由于事先与高蔗糖浓度配对而增加了风味的摄入量。这些结果表明，GluA1在适口性而不是其他特性（例如蔗糖的自动和学习的减味后营养后果）的基础上起作用。因此，Gria1 ^-/-小鼠提供了一种快感缺失症的潜在模型，为谷氨酸能功能障碍在精神分裂症和相关疾病的各种症状中的作用提供了越来越多的证据。

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GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.

The GluA1 subunit of the AMPA receptor has been implicated in schizophrenia. While GluA1 is important for cognition, it is not clear what the role of GluA1 is in hedonic responses that are relevant to the negative symptoms of disorders such as schizophrenia. Here, we tested mice that lack GluA1 (Gria1 ^-/- mice) on consumption of sucrose solutions using a licking microstructure analysis. GluA1 deletion drastically reduced palatability (as measured by the mean lick cluster size) across a range of sucrose concentrations. Although initial lick rates were reduced, measures of consumption across long periods of access to sucrose solutions were not affected by GluA1 deletion and Gria1 ^-/- mice showed normal satiety responses to high sucrose concentrations. GluA1 deletion also failed to impair flavour conditioning, in which increased intake of a flavour occurred as a consequence of prior pairing with a high sucrose concentration. These results demonstrate that GluA1 plays a role in responding on the basis of palatability rather than other properties, such as the automatic and learnt post-ingestive, nutritional consequences of sucrose. Therefore, Gria1 ^-/- mice provide a potential model of anhedonia, adding converging evidence to the role of glutamatergic dysfunction in various symptoms of schizophrenia and related disorders.

更新日期：2017-08-07

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