Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity,Chemistry of Materials

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Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity
Chemistry of Materials ( IF 7.2 ) Pub Date : 2017-08-03 00:00:00 , DOI: 10.1021/acs.chemmater.7b01979
Amir Ata Saei ₁ , Mahdieh Yazdani ₂ , Samuel E. Lohse ₃ , Zahra Bakhtiary ₄ , Vahid Serpooshan ₅ , Mahdi Ghavami ₆ , Mahtab Asadian ₇ , Samaneh Mashaghi ₈ , Erik C. Dreaden ₉ , Alireza Mashaghi _{10,

11,

12,

13,

14} , Morteza Mahmoudi ₁₅

Affiliation

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden
Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States
Physical and Environment Sciences Program, Colorado Mesa University, Grand Junction, Colorado 81501, United States
Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California 94305, United States
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen 1165, Denmark
Faculty of Engineering & Architecture, Department of Applied Physics, Research Unit Plasma Technology (RUPT), Ghent University, Ghent 9000, Belgium
School of Engineering and Applied Sciences and Department of Physics, Harvard University, 29 Oxford Street, Cambridge, Massachusetts 02138, United States
Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
Leiden Academic Centre for Drug Research, Faculty of Mathematics and Natural Sciences, Leiden University, Leiden 2311 EZ, The Netherlands
Massachusetts Eye & Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02115, United States
Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
Basir Eye Health Research Center, Tehran 1418643561, Iran
Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States

Engineered nanoparticles (NPs) have opened new frontiers in therapeutics and diagnostics in recent years. The surface functionality of these nanoparticles often predominates their interactions with various biological components of human body, and proper selection or control of surface functionality can greatly enhance subsequent therapeutic effects of NPs while diminishing their adverse side effects. In this review, we will focus on the effect of surface functionality on the cellular uptake and the transport of NPs by various subcellular processes.

中文翻译：

纳米颗粒表面功能决定细胞和系统的毒性

近年来，工程纳米颗粒（NPs）在治疗和诊断领域开辟了新的领域。这些纳米颗粒的表面功能常常占优势它们与人体，并适当选择或表面功能的控制的各种生物成分的相互作用，可以大大提高NP的后续治疗效果，同时降低其不良副作用。在这篇综述中，我们将专注于表面功能性对各种亚细胞过程对细胞摄取和NPs转运的影响。

更新日期：2017-08-04

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