18F-Deoxyfluorination of Phenols via Ru π-Complexes.,ACS Central Science

当前位置： X-MOL 学术 › ACS Cent. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

18F-Deoxyfluorination of Phenols via Ru π-Complexes.
ACS Central Science ( IF 12.7 ) Pub Date : 2017-08-03 , DOI: 10.1021/acscentsci.7b00195
M Hassan Beyzavi _{1,

2} , Debashis Mandal ₁ , Martin G Strebl _{1,

2} , Constanze N Neumann ₁ , Erica M D'Amato ₁ , Junting Chen ₃ , Jacob M Hooker _{2,

4} , Tobias Ritter _{1,

3,

4}

Affiliation

The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

中文翻译：

通过 Ru π-配合物对苯酚进行 18F-脱氧氟化。

缺乏可靠且实用的 18F 放射性氟化方法是正电子发射断层扫描 (PET) 示踪剂开发的瓶颈。在这里，我们报告了第一个过渡金属辅助的 18F 苯酚脱氧氟化反应。这种转化受益于作为起始材料的现成苯酚、对水分和环境大气的耐受性、大的基质范围以及可转化性以产生适合 PET 成像的剂量。

更新日期：2017-08-03

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南