The de novo analysis, design, and synthesis of the azaspiracid-1 trioxadispiroketal system is described. A revised structural model was developed on the basis of an independent analysis of the NMR spectral data of the natural product that fit all of the data and the thermodynamically favored spiroketal paradigm. This model was then tested via synthesis using a novel trioxadispiroketalization process and supported by spectroscopic correlation.

中文翻译：

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azaspiracid-1 trioxadispiroketal的合成。

从头开始分析，设计和合成azaspiracid-1 trioxadispiroketal系统。在对天然产物的NMR光谱数据进行独立分析的基础上，开发了修改后的结构模型，这些数据适合所有数据和热力学上优选的螺环式范式。然后使用新型三恶二螺酮金属化工艺通过合成测试了该模型，并得到了光谱相关性的支持。