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One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formation of a small oxindole library.
Organic Letters ( IF 4.9 ) Pub Date : 2004 Sep 30 , DOI: 10.1021/ol048759t
Antje Teichert 1 , Katja Jantos 1 , Klaus Harms 1 , Armido Studer 1
Affiliation  

[reaction: see text] An efficient one-pot sequence comprising a homolytic aromatic substitution followed by an ionic Horner-Wadsworth-Emmons olefination for the preparation of a small library of alpha,beta-unsaturated oxindoles is presented. Microwave-induced heating is used to conduct these reactions. The homolytic aromatic substitution is mediated by the persistent radical effect.

中文翻译:

在微波条件下进行一锅均质芳族取代/ HWE烯烃化反应,以形成一个小的羟吲哚文库。

[反应:见正文]提出了一种有效的一锅法序列,该序列包括一个均质芳族取代基,然后进行离子霍纳-沃兹沃思-埃蒙斯离子化烯烃反应,以制备一个小的α,β-不饱和羟吲哚文库。微波诱导的加热用于进行这些反应。均相芳族取代是由持久自由基作用介导的。
更新日期:2017-01-31
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