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A Hollow‐Structured CuS@Cu2S@Au Nanohybrid: Synergistically Enhanced Photothermal Efficiency and Photoswitchable Targeting Effect for Cancer Theranostics
Advanced Materials ( IF 27.4 ) Pub Date : 2017-07-26 , DOI: 10.1002/adma.201701266 Xiaoran Deng 1, 2 , Kai Li 1 , Xuechao Cai 1, 2 , Bin Liu 1 , Yi Wei 1, 2 , Kerong Deng 1, 2 , Zhongxi Xie 1, 2 , Zhijian Wu 1 , Ping'an Ma 1 , Zhiyao Hou 1 , Ziyong Cheng 1 , Jun Lin 1
Advanced Materials ( IF 27.4 ) Pub Date : 2017-07-26 , DOI: 10.1002/adma.201701266 Xiaoran Deng 1, 2 , Kai Li 1 , Xuechao Cai 1, 2 , Bin Liu 1 , Yi Wei 1, 2 , Kerong Deng 1, 2 , Zhongxi Xie 1, 2 , Zhijian Wu 1 , Ping'an Ma 1 , Zhiyao Hou 1 , Ziyong Cheng 1 , Jun Lin 1
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It is of great importance in drug delivery to fabricate multifunctional nanocarriers with intelligent targeting properties, for cancer diagnosis and therapy. Herein, hollow‐structured CuS@Cu2S@Au nanoshell/satellite nanoparticles are designed and synthesized for enhanced photothermal therapy and photoswitchable targeting theranostics. The remarkably improved photothermal conversion efficiency of CuS@Cu2S@Au under 808 nm near‐infrared (NIR) laser irradiation can be explained by the reduced bandgap and more circuit paths for electron transitions for CuS and Cu2S modified with Au nanoparticles, as calculated by the Vienna ab initio simulation package, based on density functional theory. By modification of thermal‐isomerization RGD targeting molecules and thermally sensitive copolymer on the surface of nanoparticles, the transition of the shielded/unshielded mode of RGD (Arg‐Gly‐Asp) targeting molecules and shrinking of the thermally sensitive polymer by NIR photoactivation can realize a photoswitchable targeting effect. After loading an anticancer drug doxorubicin in the cavity of CuS@Cu2S@Au, the antitumor therapy efficacy is greatly enhanced by combining chemo‐ and photothermal therapy. The reported nanohybrid can also act as a photoacoustic imaging agent and an NIR thermal imaging agent for real‐time imaging, which provides a versatile platform for multifunctional theranostics and stimuli‐responsive targeted cancer therapy.
中文翻译：
空心结构的CuS @ Cu2S @ Au纳米杂化物：协同增强的光热效率和光可切换靶向治疗肿瘤治疗。
在药物递送中，制造具有智能靶向特性的多功能纳米载体对于癌症诊断和治疗非常重要。本文中，设计并合成了中空结构的CuS @ Cu 2 S @ Au纳米壳/卫星纳米颗粒，用于增强的光热疗法和可光转换的靶向治疗学。在808 nm近红外（NIR）激光照射下，CuS @ Cu 2 S @ Au的光热转换效率显着提高，这可以通过减少带隙和更多的CuS和Cu 2电子跃迁的电路路径来解释根据密度泛函理论，由Vienna从头算模拟程序计算得出的用Au纳米粒子修饰的S。通过修饰热异构化RGD靶向分子和纳米颗粒表面上的热敏共聚物，可以实现RGD（Arg-Gly-Asp）靶向分子的屏蔽/非屏蔽模式的转变以及通过NIR光活化引起的热敏聚合物的收缩可光电转换的瞄准效果。在将抗癌药阿霉素加载到CuS @ Cu 2的腔中后S @ Au，化学和光热疗法相结合，大大提高了抗肿瘤疗法的疗效。报道的纳米杂交体还可以充当光声成像剂和近红外热成像剂以进行实时成像，这为多功能治疗学和刺激响应的靶向癌症治疗提供了一个多功能平台。
更新日期：2017-07-26
中文翻译：
空心结构的CuS @ Cu2S @ Au纳米杂化物：协同增强的光热效率和光可切换靶向治疗肿瘤治疗。
在药物递送中，制造具有智能靶向特性的多功能纳米载体对于癌症诊断和治疗非常重要。本文中，设计并合成了中空结构的CuS @ Cu 2 S @ Au纳米壳/卫星纳米颗粒，用于增强的光热疗法和可光转换的靶向治疗学。在808 nm近红外（NIR）激光照射下，CuS @ Cu 2 S @ Au的光热转换效率显着提高，这可以通过减少带隙和更多的CuS和Cu 2电子跃迁的电路路径来解释根据密度泛函理论，由Vienna从头算模拟程序计算得出的用Au纳米粒子修饰的S。通过修饰热异构化RGD靶向分子和纳米颗粒表面上的热敏共聚物，可以实现RGD（Arg-Gly-Asp）靶向分子的屏蔽/非屏蔽模式的转变以及通过NIR光活化引起的热敏聚合物的收缩可光电转换的瞄准效果。在将抗癌药阿霉素加载到CuS @ Cu 2的腔中后S @ Au，化学和光热疗法相结合，大大提高了抗肿瘤疗法的疗效。报道的纳米杂交体还可以充当光声成像剂和近红外热成像剂以进行实时成像，这为多功能治疗学和刺激响应的靶向癌症治疗提供了一个多功能平台。
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