Triggerable tough hydrogels for gastric resident dosage forms.,Nature Communications

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Triggerable tough hydrogels for gastric resident dosage forms.
Nature Communications ( IF 14.7 ) Pub Date : 2017-07-25 , DOI: 10.1038/s41467-017-00144-z
Jinyao Liu ₁ , Yan Pang ₁ , Shiyi Zhang ₁ , Cody Cleveland _{1,

2} , Xiaolei Yin ₁ , Lucas Booth ₁ , Jiaqi Lin ₁ , Young-Ah Lucy Lee ₁ , Hormoz Mazdiyasni ₁ , Sarah Saxton ₁ , Ameya R Kirtane ₁ , Thomas von Erlach ₁ , Jaimie Rogner ₁ , Robert Langer _{1,

3} , Giovanni Traverso _{1,

2}

Affiliation

Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets. Here we describe a novel set of materials, triggerable tough hydrogels, meeting all these requirement, supported by evaluation in a large animal model and ultimately demonstrate the potential of triggerable tough hydrogels to serve as prolonged gastric resident drug depots. Triggerable tough hydrogels may be applied in myriad of applications, including bariatric interventions, drug delivery, and tissue engineering.The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.

中文翻译：

用于胃驻留剂型的可触发坚韧水凝胶。

能够在胃腔中长时间驻留的系统已经改变了我们诊断和治疗患者的能力。用于药物输送的胃驻留系统理想地需要：可摄入、能够改变形状或膨胀以确保延长胃停留时间、具有机械完整性以承受与胃肠运动相关的力、可触发以解决任何副作用，并且可负载药物并在较长时间内释放药物。主要用于这些应用的材料主要限于热塑性塑料和热固性塑料。在这里，我们描述了一组新颖的材料，即可触发的坚韧水凝胶，满足所有这些要求，并得到大型动物模型评估的支持，并最终证明了可触发的坚韧水凝胶作为长期胃驻留药物库的潜力。可触发的坚韧水凝胶可用于多种应用，包括减肥干预、药物递送和组织工程。胃肠道药物递送系统的使用面临着与其长期使用相关的许多缺点。在这里，作者开发了一种高强度的载药水凝胶，可以承受长期的胃肠蠕动，并且可以根据需要触发溶解。

更新日期：2017-07-26

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