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myo-Inositol-1,2,3,4,5,6-hexakisphosphate.
Phytochemistry ( IF 3.2 ) Pub Date : 2003 Nov
Raboy, Victor

myo-Inositol-1,2,3,4,5,6-hexakisphosphate (Ins P(6)) was first described as an abundant form of phosphorus in plant seeds and other plant tissues and dubbed "phytic acid". Subsequently it was found to be a common constituent in eukaryotic cells, its metabolism a basic component of cellular housekeeping. In addition to phosphate, myo-inositol (Ins) and mineral storage and retrieval in plant organs and tissues, other roles for Ins P(6) include service as a major metabolic pool in Ins phosphate and pyrophosphate pathways involved in signaling and regulation; possibly as an effector or ligand in these processes; as a form of energy currency and in ATP regeneration; in RNA export and DNA repair; and as an anti-oxidant. The relatively recent demonstration that pyrophosphate-containing derivatives of Ins P(6) can function as phosphate donors in the regeneration of ATP is reminiscent of the proposal, made four decades ago in studies of seed development, that Ins P(6) itself may serve in this function. Studies of Ins P(6) in non-plant systems rarely include the consideration that this compound might represent a significant fraction of cellular P; cellular phosphate nutrition has been viewed as either not interesting or of little importance. However, there may be few fundamental differences among diverse eukaryotes in both the metabolic pathways involving Ins P(6) and the spectrum of possible roles for it and its metabolites.

中文翻译:

肌醇-1,2,3,4,5,6-六六磷酸。

肌醇-1,2,3,4,5,6-六磷酸(Ins P(6))首先被描述为植物种子和其他植物组织中磷的丰富形式,被称为“植酸”。随后发现它是真核细胞中的常见成分,其代谢是细胞内务处理的基本组成部分。除了磷酸盐,肌醇(Ins)以及植物器官和组织中的矿物质存储和检索之外,Ins P(6)的其他作用还包括作为Ins磷酸盐和焦磷酸盐途径中的主要代谢库,参与信号传递和调控。在这些过程中可能作为效应子或配体;作为一种能源货币和ATP再生;RNA出口和DNA修复;并作为抗氧化剂。Ins P(6)的含焦磷酸盐衍生物可以在ATP的再生中充当磷酸盐供体的相对较近期的证明使人想起了四年前在种子发育研究中提出的Ins P(6)本身可以起到的作用的提议。在此功能中。在非植物系统中对Ins P(6)的研究很少包括考虑到该化合物可能代表了细胞P的重要部分。人们已经认为细胞磷酸盐营养既不有趣也不重要。但是,在涉及Ins P(6)的代谢途径以及其及其代谢物可能作用的范围内,各种真核生物之间可能几乎没有根本差异。Ins P(6)本身可以起到此功能。在非植物系统中对Ins P(6)的研究很少包括考虑到该化合物可能代表了细胞P的重要部分。人们已经认为细胞磷酸盐营养既不有趣也不重要。但是,在涉及Ins P(6)的代谢途径以及其及其代谢物可能作用的范围内,各种真核生物之间可能几乎没有根本差异。Ins P(6)本身可以起到此功能。在非植物系统中对Ins P(6)的研究很少包括考虑到该化合物可能代表了细胞P的重要部分。人们已经认为细胞磷酸盐营养既不有趣也不重要。但是,在涉及Ins P(6)的代谢途径以及其及其代谢物可能作用的范围内,各种真核生物之间可能几乎没有根本差异。
更新日期:2017-01-31
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