A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis,Advanced Materials

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A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis
Advanced Materials ( IF 27.4 ) Pub Date : 2017-07-17 , DOI: 10.1002/adma.201702243
Hao Chang ₁ , Mengjia Zheng ₁ , Xiaojun Yu ₂ , Aung Than ₁ , Razina Z. Seeni ₁ , Rongjie Kang ₁ , Jingqi Tian ₁ , Duong Phan Khanh ₁ , Linbo Liu ₂ , Peng Chen ₁ , Chenjie Xu _{1,

3}

Affiliation

Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF from the skin due to its pain‐free and easy‐to‐administrated properties. However, long sampling time is still a serious problem which impedes timely metabolic analysis. In this study, a swellable MN patch that can rapidly extract ISF is developed. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through UV irradiation. Owing to the supreme water affinity of MeHA, this MN patch can extract sufficient ISF in a short time without the assistance of extra devices, which remarkably facilitates timely metabolic analysis. Due to covalent crosslinked network, the MN patch maintains the structure integrity in the swelling hydrated state without leaving residues in skin after usage. More importantly, the extracted ISF metabolites can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol. Given the recent trend of easy‐to‐use point‐of‐care devices for personal healthcare monitoring, this study opens a new avenue for the development of MN‐based microdevices for sampling ISF and minimally invasive metabolic detection.

中文翻译：

一种可膨胀的微针贴片，可快速提取皮肤组织液，以便及时进行代谢分析

皮肤间质液（ISF）是用于疾病诊断和预后的生物标志物的新兴来源。微针（MN）贴剂具有无痛且易于管理的特性，因此已被认为是从皮肤中提取ISF的理想平台。然而，长采样时间仍然是严重的问题，阻碍了及时的代谢分析。在这项研究中，开发了一种可快速提取ISF的可膨胀MN贴片。MN贴片由甲基丙烯酸透明质酸（MeHA）制成，并通过UV辐射进一步交联。由于MeHA具有极高的水亲和力，因此该MN贴片可在短时间内提取出足够的ISF，而无需额外的设备，这极大地促进了及时的代谢分析。由于共价交联网络，MN贴片在膨胀水合状态下保持结构完整性，使用后不会在皮肤上留下残留物。更重要的是，可以通过离心从MN斑块中高效回收提取的ISF代谢物，用于随后的代谢物（例如葡萄糖和胆固醇）的离线分析。考虑到用于个人医疗保健监控的易于使用的即时护理设备的最新趋势，本研究为基于MN的微设备的开发开辟了新途径，该微设备用于采样ISF和微创代谢检测。

更新日期：2017-07-17

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