An improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt is reported. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, nonhygroscopic solid that is a convenient form for handling and storage.

中文翻译：

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N-[（2-Boc-氨基）乙基]甘氨酸乙酯及其盐酸盐的便捷，可扩展合成。肽核酸合成的关键中间体。

据报道，N-[（2-Boc-氨基）乙基]甘氨酸乙酯及其盐酸盐的合成得到改进。该合成是基于Boc-乙二胺与乙醛酸乙酯水合物的还原烷基化，并且无需色谱即可以接近定量的收率和高纯度提供标题化合物。该化合物原样适合于合成肽核酸单体。此外，转化为盐酸盐提供了稳定的，不吸湿的固体，这是用于处理和储存的方便形式。