Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH,Angewandte Chemie International Edition

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Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-09-22 , DOI: 10.1002/anie.201704084
Cai-Xia Yin ₁ , Kang-Ming Xiong ₁ , Fang-Jun Huo ₂ , James C. Salamanca ₃ , Robert M. Strongin ₃

Affiliation

Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial roles in maintaining redox homeostasis in biological systems. This Minireview summarizes the most significant current challenges in the field of thiol‐reactive probes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been under‐investigated by chemists in the selective probe and sensor field. Progress on multiple binding site probes to distinguish Cys, Hcy, and GSH is highlighted as a creative new direction in the field that can enable simultaneous, accurate ratiometric monitoring. New probe design strategies and researcher priorities can better help address current challenges, including the monitoring of disease states such as autism and chronic diseases involving oxidative stress that are characterized by divergent levels of GSH, Cys, and Hcy.

中文翻译：

具有多个结合位点的荧光探针，用于区分Cys，Hcy和GSH

半胱氨酸（Cys），高半胱氨酸（Hcy）和谷胱甘肽（GSH）等生物硫醇在维持生物系统中的氧化还原稳态方面起着至关重要的作用。本小型审查总结了用于生物医学研究和诊断的硫醇反应性探针领域当前最重大的挑战，强调了化学家在选择性探针和传感器领域尚未充分研究的需求和机会。在区分结合Cys，Hcy和GSH的多个结合位点探针上的进展被突出显示为该领域中一个创新的新方向，可以实现同步，准确的比率监测。新的探针设计策略和研究人员的优先重点可以更好地帮助应对当前的挑战，

更新日期：2017-09-22

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