Ambient-temperature reactions of electron-rich aryl isonitriles with substituted 6-iodo-N-propargylpyridones in the presence of silver carbonate and palladium acetate produce 11H-indolizino[1,2-b]quinolin-9-ones in good to excellent yield. Experimental evidence suggests that the process occurs though organopalladium rather than radical intermediates. It is applied to synthesis analogues of mappicine and camptothecin, including the silatecans DB-67 and DB-91 (homo-DB-67).

中文翻译：

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钯促进的异腈和6-碘-N-炔丙基吡啶酮的级联反应：合成苦瓜碱，喜树碱和高喜树碱。

在碳酸银和乙酸钯存在下，富电子芳基异腈与取代的6-碘-N-炔丙基吡啶酮的环境温度反应可很好地产生11H-吲哚并[1,2-b]喹啉-9-。实验证据表明，该过程是通过有机钯而不是自由基中间体发生的。它可用于马比卡因和喜树碱的合成类似物，包括硅酸根DB-67和​​DB-91（homo-DB-67）。