Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications,ACS Biomaterials Science & Engineering

当前位置： X-MOL 学术 › ACS Biomater. Sci. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2016-09-13 00:00:00 , DOI: 10.1021/acsbiomaterials.6b00355
Natalie A. Parlane ₁ , Sandeep K. Gupta ₁ , Patricia Rubio-Reyes ₂ , Shuxiong Chen ₂ , Majela Gonzalez-Miro ₂ , D. Neil Wedlock ₁ , Bernd H. A. Rehm _{2,

3}

Affiliation

Polyhydroxyalkanoates (PHAs) are biological polyesters that can be naturally produced by a range of bacteria as water-insoluble inclusions composed of a PHA core coated with PHA synthesis, structural, and regulatory proteins. These naturally self-assembling shell–core particles have been recently conceived as biomaterials that can be bioengineered as biologically active beads for medical applications. Protein engineering of PHA-associated proteins enabled the production of PHA–protein assemblies exhibiting biologically active protein-based functions relevant for applications as vaccines or diagnostics. Here we provide an overview of the recent advances in bioengineering of PHA particles toward the display of biomedically relevant protein functions such as selected disease-specific antigens as diagnostic tools or for the design of particulate subunit vaccines against infectious diseases such as tuberculosis, meningitis, pneumonia, and hepatitis C.

中文翻译：

自组装蛋白包衣的聚羟基链烷酸酯珠：性质和生物医学应用。

聚羟基链烷酸酯（PHA）是一种生物聚酯，可由多种细菌作为不溶于水的内含物由多种细菌天然产生，这些内含物由涂有PHA合成，结构和调节蛋白的PHA核心组成。这些自然自组装的壳核颗粒最近被认为是生物材料，可以将其生物工程化为具有生物活性的珠子，以用于医疗应用。与PHA相关的蛋白质的蛋白质工程改造使得PHA蛋白质装配体的生产具有了基于生物活性蛋白质的功能，这些功能与疫苗或诊断试剂的应用有关。

更新日期：2016-09-13

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南