Dodecyl (C12) gallate exhibits both potent chain-breaking and preventive antioxidant activity. The pyrogallol moiety is responsible for both activities. Dodecyl (lauryl) gallate prevents generation of superoxide radicals by xanthine oxidase, and this activity comes from its ability to inhibit the enzyme. The inhibition kinetics analyzed by Lineweaver-Burk plots found that dodecylgallate is a noncompetitive inhibitor for the generation of superoxide anion. Dodecyl gallate also inhibits formation of uric acid. The inhibition kinetics analyzed by Lineweaver-Burk plots found that dodecyl gallate is a competitive inhibitor for this oxidation. Mitochondrial lipid peroxidation induced by Fe(III)-adenosine 5'-diphosphate/reduced nicotinamide adenine dinucleotide was inhibited by dodecyl gallate while its parent compound, gallic acid, did not show this inhibitory activity. Dodecyl gallate protected mitochondrial functions and human red blood cells against oxidative stresses, but gallic acid showed little effect. The hydrophobic dodecyl group is largely associated with the preventive antioxidative activity.

中文翻译：

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十二烷基没食子酸酯的抗氧化活性。

十二烷基没食子酸酯（C12）表现出强力的链断裂和预防性抗氧化活性。联苯三酚部分负责这两个活动。十二烷基（月桂基）没食子酸酯可防止黄嘌呤氧化酶产生超氧自由基，这种活性来自其抑制酶的能力。通过Lineweaver-Burk图分析的抑制动力学发现，十二烷基没食子酸酯是产生超氧阴离子的非竞争性抑制剂。没食子酸十二烷基酯也抑制尿酸的形成。通过Lineweaver-Burk图分析的抑制动力学发现，十二烷基没食子酸酯是这种氧化的竞争性抑制剂。十二烷基没食子酸酯抑制Fe（III）-腺苷5'-二磷酸/还原烟酰胺腺嘌呤二核苷酸诱导的线粒体脂质过氧化。没有显示出这种抑制活性。没食子酸十二烷基酯保护线粒体功能和人类红细胞免受氧化应激，但是没食子酸几乎没有作用。疏水性十二烷基很大程度上与预防性抗氧化活性有关。