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An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2002 Apr 22 Tanimori, Shinji, Ohta, Takeshi, Kirihata, Mitsunori
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2002 Apr 22 Tanimori, Shinji, Ohta, Takeshi, Kirihata, Mitsunori
A simple and efficient synthesis of nicotinamide riboside (NAR) 1 and derivatives 4 and 5 via trimethylsilyl trifluoromethanesulfonate (TMSOTf)-mediated N-glycosilation followed by spontaneous deacetylation by treating with methanol is reported.
中文翻译:
烟酰胺核糖苷(NAR)和类似物的有效化学合成。
据报道,通过三甲基甲硅烷基三氟甲磺酸酯(TMSOTf)介导的N-糖基硅烷化,然后通过用甲醇处理自发脱乙酰基,可以简单有效地合成烟酰胺核糖苷(NAR)1和衍生物4和5。
更新日期:2017-01-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
烟酰胺核糖苷(NAR)和类似物的有效化学合成。
据报道,通过三甲基甲硅烷基三氟甲磺酸酯(TMSOTf)介导的N-糖基硅烷化,然后通过用甲醇处理自发脱乙酰基,可以简单有效地合成烟酰胺核糖苷(NAR)1和衍生物4和5。