[reaction: see text] Data are presented indicating that the potent antitumor activity of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxy-2-cyclohexenone (COTC) and 2-crotonyloxymethyl-2-cyclohexenone (COMC) is not likely the result of glyoxalase I inhibition, as has long been assumed. An alternative hypothesis is presented, based on the finding that COMC is a substrate for human glutathionyl transferase, which produces a transient, highly electrophilic glutathionylated 2-exomethylenecyclohexanone that can covalently modify proteins and nucleic acids.

中文翻译：

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谷胱甘肽转移酶催化向COMC添加谷胱甘肽：抗肿瘤活性的新假设。

[反应：参见正文]数据表明2-巴豆酰氧基甲基-（4R，5R，6R）-4,5,6-三羟基-2-环己烯酮（COTC）和2-巴豆酰氧基甲基-2-环己烯酮具有较强的抗肿瘤活性（COMC）不太可能是乙二醛酶I抑制的结果，正如长期以来所假设的那样。基于以下发现，提出了另一种假设：COMC是人谷胱甘肽转移酶的底物，该酶产生一种瞬时的，高度亲电的谷胱甘肽化的2-exomethylcyclohexanone，可以共价修饰蛋白质和核酸。