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X-ray-Activated Near-Infrared Persistent Luminescent Probe for Deep-Tissue and Renewable in Vivo Bioimaging
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-06-26 00:00:00 , DOI: 10.1021/acsami.7b03802 Zhenluan Xue 1 , Xiaolong Li 1 , Youbin Li 1 , Mingyang Jiang 1 , Hongrong Liu 1 , Songjun Zeng 1 , Jianhua Hao 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-06-26 00:00:00 , DOI: 10.1021/acsami.7b03802 Zhenluan Xue 1 , Xiaolong Li 1 , Youbin Li 1 , Mingyang Jiang 1 , Hongrong Liu 1 , Songjun Zeng 1 , Jianhua Hao 2
Affiliation
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Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) are considered as new alternative optical probes due to being free of autofluorescence, benefited from the self-sustained emission after excitation and high signal-to-noise ratio. However, the NIR-emitted PLNPs always present a short decay time and require excitation by ultraviolet or visible light with a short penetrable depth, remarkably hindering their applications for in vivo long-term tracking and imaging. Therefore, it is important to develop NIR-emitted PLNPs with in vivo activation nature by new excitation sources with deeper penetrating depths. Here, we propose a new type of X-ray-activated ZnGa2O4:Cr PLNPs (X-PLNPs) with efficient NIR persistent emission and rechargeable activation features, in which both the excitation and emission possess a high penetrable nature in vivo. These X-PLNPs exhibit long-lasting, up to 6 h, NIR emission at 700 nm after the stoppage of the X-ray excitation source. More importantly, the designed X-PLNPs can be readily reactivated by a soft X-ray excitation source with low excitation power (45 kVp, 0.5 mA) to restore in vivo bioimaging signals even at 20 mm depth. Renewable in vivo whole-body bioimaging was also successfully achieved via intravenous injection/oral administration of X-PLNPs after in situ X-ray activation. This is the first time that NIR-emitted PLNPs have been demonstrated to be recharged by X-ray light for deep-tissue in vivo bioimaging, which paves the way for in vivo renewable bioimaging using PLNPs and makes the PLNPs more competitive in bioimaging area.
中文翻译：
X射线激活近红外持久发光探针，用于深部组织和体内生物成像的可更新性。
由于没有自发荧光，近红外（NIR）持久发光纳米粒子（PLNP）被认为是新的替代光学探针，得益于激发后的自持发射和高信噪比。然而，NIR发射的PLNP总是呈现较短的衰减时间，并且需要具有短的可穿透深度的紫外线或可见光激发，这显着阻碍了它们在体内长期跟踪和成像中的应用。因此，重要的是通过具有更深穿透深度的新型激发源来开发具有体内激活性质的近红外发射PLNP。在这里，我们提出了一种新型的X射线活化ZnGa 2 O 4：Cr PLNP（X-PLNP）具有有效的NIR持续发射和可充电激活功能，其中激发和发射在体内均具有高穿透性。在停止X射线激发源之后，这些X-PLNP在700 nm处表现出持续长达6小时的NIR发射。更重要的是，设计的X-PLNP可以很容易地由具有低激发功率（45 kVp，0.5 mA）的软X射线激发源重新激活，以恢复甚至在20 mm深度的体内生物成像信号。在原位X射线激活后，通过静脉注射/口服X-PLNPs也成功地实现了可更新的体内全身生物成像。这是首次证明NIR发射的PLNP可通过X射线对体内深部组织生物成像进行充电，
更新日期：2017-06-28
中文翻译：
X射线激活近红外持久发光探针，用于深部组织和体内生物成像的可更新性。
由于没有自发荧光，近红外（NIR）持久发光纳米粒子（PLNP）被认为是新的替代光学探针，得益于激发后的自持发射和高信噪比。然而，NIR发射的PLNP总是呈现较短的衰减时间，并且需要具有短的可穿透深度的紫外线或可见光激发，这显着阻碍了它们在体内长期跟踪和成像中的应用。因此，重要的是通过具有更深穿透深度的新型激发源来开发具有体内激活性质的近红外发射PLNP。在这里，我们提出了一种新型的X射线活化ZnGa 2 O 4：Cr PLNP（X-PLNP）具有有效的NIR持续发射和可充电激活功能，其中激发和发射在体内均具有高穿透性。在停止X射线激发源之后，这些X-PLNP在700 nm处表现出持续长达6小时的NIR发射。更重要的是，设计的X-PLNP可以很容易地由具有低激发功率（45 kVp，0.5 mA）的软X射线激发源重新激活，以恢复甚至在20 mm深度的体内生物成像信号。在原位X射线激活后，通过静脉注射/口服X-PLNPs也成功地实现了可更新的体内全身生物成像。这是首次证明NIR发射的PLNP可通过X射线对体内深部组织生物成像进行充电，
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