Discovery and Synthesis of Boletopsins 13 and 14, Brominated Fungal Metabolites of Terrestrial Origin,Journal of Natural Products

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Discovery and Synthesis of Boletopsins 13 and 14, Brominated Fungal Metabolites of Terrestrial Origin
Journal of Natural Products ( IF 3.3 ) Pub Date : 2015-07-24 00:00:00 , DOI: 10.1021/acs.jnatprod.5b00202
Andrew M. Beekman ₁ , Stewart W. Wossa _{1,

2} , Oromo Kevo ₃ , Paul Ma ₁ , Russell A. Barrow _{1,

2}

Affiliation

Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.

中文翻译：

陆地来源的溴化菌素13和14的发现和合成，溴化真菌代谢产物

在这里，我们报道了从巴布亚新几内亚高地的科维奇人用作传统药物的蘑菇（Boletopsis sp。）分离出的复杂多溴对-三苯醚的发现和合成。Boletopsins 13和14代表了陆生真菌产生的多溴化真菌代谢产物的首次报道。该合成方法采用2,4,4,6-四溴-2,5-环己二酮以选择性和顺序的方式实现扩展的芳族体系的选择性多溴化。

更新日期：2015-07-24

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