Cesium Removal from Human Blood by Poly(ethylene glycol)-Decorated Prussian Blue Magnetic Nanoparticles.,ChemPlusChem

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Cesium Removal from Human Blood by Poly(ethylene glycol)-Decorated Prussian Blue Magnetic Nanoparticles.
ChemPlusChem ( IF 3.0 ) Pub Date : 2017-06-01 , DOI: 10.1002/cplu.201700183
Jun Qian ₁ , Jiaying Xu ₁ , Liangju Kuang ₂ , Daoben Hua _{1,

3}

Affiliation

The current oral administration of drugs for cesium (Cs) decorporation treatment are often subject to side effects and low efficiency. Therefore, it is of great significance, yet challenging, to develop novel materials and techniques for efficient removal of Cs from the human body. We report herein a new method for directly removing cesium from blood by poly(ethylene glycol)-decorated Prussian blue magnetic nanoparticles (PEG-PB MNs). The nanoparticles have been successfully synthesized by one-pot hydrothermal reaction. The adsorption of cesium in aqueous solution is a highly selective process and kinetically follows a pseudo-second-order model, which can reach equilibrium with a large capacity of 274.7 mg Cs g-1 within one hour at 298.15 K. PEG-PB MNs were also efficiently regenerated and reused with high adsorption efficiency after five cycles. The nanoparticles successfully removed cesium ions from human blood with improved biocompatibility. The removal efficiency achieved 64 % in the blood with an initial Cs concentration of 168.4 ppb. This study provides a new approach to directly remove cesium ions from the human body by utilizing biocompatible Prussian blue magnetic nanoparticles.

中文翻译：

聚乙二醇修饰的普鲁士蓝磁性纳米粒子从人血中去除铯。

当前用于铯（Cs）分解治疗的药物的口服给药经常会出现副作用和低效。因此，开发新颖的材料和技术以从人体中有效去除Cs具有重要意义，但也具有挑战性。我们在此报告了一种通过聚（乙二醇）修饰的普鲁士蓝磁性纳米颗粒（PEG-PB MNs）直接从血液中去除铯的新方法。通过一锅水热反应已经成功地合成了纳米颗粒。铯在水溶液中的吸附是一个高度选择性的过程，并且在动力学上遵循伪二级模型，该模型在298.15 K下在一小时内可达到平衡，并具有274.7 mg Cs g-1的大容量。在五个循环后，还可以高效地再生并以高吸附效率进行再利用。纳米粒子以改善的生物相容性成功地从人血中去除了铯离子。在血液中的去除效率达到64％，初始Cs浓度为168.4 ppb。这项研究提供了一种利用生物相容性普鲁士蓝磁性纳米粒子直接从人体中去除铯离子的新方法。

更新日期：2017-06-21

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